Kenyan Health Patient Information Leaflet
Therapeutic agent (verify pharmacological class)
Symptomatic anaemia associated with CRF in adults and paediatrics; prevention of anaemia of prematurity in infants with a birth weight of 0.75-1.5kg and a gestational age < 34 wks; symptomatic anaemia in adult patients with non-myeloid malignancies receiving chemotherapy; increasing the yield of autologous blood from patients in a pre-donation programme.
Dose:SC: Initial dose: 3 x 20 IU/kg/wk increased every 4 wks by 3 x 20 IU/kg/ wk if the increase of Hb is < 0.25 g/dl/wk. IV: The initial dose: 3 x 40 IU/kg/wk increased after 4 wks to 80 IU/kg x 3 wkly up to 20 IU/kg x 3 per week, at monthly intervals [maximum dose < 720 IU/kg/wk. Main-tainance dose titrated to produce Hb of 10-12 g/dl
Hypertension; diarrhea; naso-pharyngitis; headache; URTI; coronary artery disease; septic shock; increased mortality; pure red cell aplasia; serious cardiovascular and thromboembolic events.
16 HOW SUPPLIED/STORAGE AND HANDLING PROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as: Preservative-free, single-dose vials (in citrate-buffered formulation) : 2,000 Units/mL (NDC 59676-302-01), 3,000 Units/mL (NDC 59676-303-01), 4,000 Units/mL (NDC 59676-304-01), or 10,000 Units/mL (NDC 59676-310-01) supplied in cartons, each carton containing six 1 mL single-dose vials. Preservative-free, single-dose vials (in citrate-buffered formulation) : 10,000 Units/mL (NDC 59676-310-02) supplied in dispensing packs (tray) containing 25 single-dose 1 mL vials. Preservative-free, single-dose vials (in phosphate-buffered formulation) : 40,000 Units/mL (NDC 59676-340-01) supplied in dispensing packs containing four 1 mL single-dose vials. Preserved, multiple-dose vials : 20,000 Units/2mL (10,000 Units/mL) (NDC 59676-312-04) supplied in dispensing packs containing four 2 mL multiple-dose vials. Preserved, multiple-dose vials : 20,000 Units/mL (NDC 59676-320-04) supplied in dispensing packs containing four 1 mL multiple-dose vials. Store at 36°F to 46°F (2°C to 8°C). Do not freeze. Do not shake. Do not use PROCRIT that has been shaken or frozen. Store PROCRIT vials in the original carton until use to protect from light.