Metformin / Glibenclamide
Biguanide antidiabetic
What it is used for
Uncomplicated and non-ketonic diabetes mellitus (maturity onset type II diabetes). Clinical selection for Metformin / Glibenclamide should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC. Class context: Biguanide antidiabetic. Confirm site-specific dose, duration and monitoring before prescribing.
Warnings
Hold around iodinated contrast if eGFR low (local protocol). B12 deficiency with long-term use — monitor if anaemic/neuropathy. GI titration improves tolerability. XR formulations reduce GI effects.
Possible side effects
[Metformin] Diarrhoea, nausea, abdominal discomfort, metallic taste. Serious: lactic acidosis (rare, high mortality if occurs). [Glibenclamide] GI disturbances; blood dyscrasia; hypoglycaemia; jaundice; skin rashes; hypersensitivity reactions; headache; dizziness; oedema; hyponatraemia; paraesthesia; photosensitivity.
Storage
Store as labelled. Keep out of reach of children.
No reviewed patient-education article is available. The fields shown are from the currently verified medicine record and unavailable fields are not inferred.