Metronidazole / Diloxanide
Nitroimidazole antimicrobial / antiprotozoal
What it is used for
Diloxanide furoate is active against the cystic form of amoeba. Hence the combination is effective in all forms of amoebiasis. Clinical selection for Metronidazole / Diloxanide should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC. Class context: Nitroimidazole antimicrobial / antiprotozoal. Confirm site-specific dose, duration and monitoring before prescribing.
Warnings
Avoid alcohol during and for 24–72 h after (disulfiram-like reaction). Neurologic toxicity with prolonged/high dose (neuropathy, seizures). Metallic taste common. Dark urine possible.
Possible side effects
GI discomfort, anorexia, metallic taste, dry mouth, headache, skin rash, vertigo, depression, insomnia, drowsiness, urethral dis- comfort, darkened urine, transient fall in BP, temporary leucopenia, bone marrow depression, transient epileptic seizure, furred tongue.
Storage
Store as labelled. Keep out of reach of children.
No reviewed patient-education article is available. The fields shown are from the currently verified medicine record and unavailable fields are not inferred.