Metronidazole / Diloxanide / Simethicone
Nitroimidazole antimicrobial / antiprotozoal
What it is used for
see under metronidazole, diloxanide and simethicone respectively. Clinical selection for Metronidazole / Diloxanide / Simethicone should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC. Class context: Nitroimidazole antimicrobial / antiprotozoal. Confirm site-specific dose, duration and monitoring before prescribing.
Warnings
Avoid alcohol during and for 24–72 h after (disulfiram-like reaction). Neurologic toxicity with prolonged/high dose (neuropathy, seizures). Metallic taste common. Dark urine possible.
Possible side effects
[Metronidazole] GI discomfort, anorexia, metallic taste, dry mouth, headache, skin rash, vertigo, depression, insomnia, drowsiness, urethral dis- comfort, darkened urine, transient fall in BP, temporary leucopenia, bone marrow depression, transient epileptic seizure, furred tongue. [Simethicone] Adverse reactions vary by agent. Counsel on common predictable effects and serious warning symptoms (allergy, severe rash, jaundice, unusual bleeding, severe GI symptoms, neurological changes). Report suspected ADRs via national pharmacovigilance channels.
Storage
Store as labelled. Keep out of reach of children.
No reviewed patient-education article is available. The fields shown are from the currently verified medicine record and unavailable fields are not inferred.