Clinical medicine profile
Metopine / Lysine / Carnitine / Vit B1 / B6 / B12
Therapeutic agent (verify pharmacological class)
- Route
- See product SmPC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
Some sections contain general class guidance rather than medicine-specific evidence. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- [From component Lysine acetyl salicylate] Hypersensitivity to NSAIDs, asthma, nasal polyposis, chronic urticaria, haemophilia, bleeding ulcer, haemorrhagic states.
Precautions
- [From component Lysine acetyl salicylate] Renal impairment, gastric ulcers, mild diabetes, gout, severe anaemia, history of blood coagulation defects and those on anti-coagulants.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
Children: up to 3 years-2.5mL TID, 3- 6 years: 5mL TID. Adults and children over 6yrs: 5-10ml TID. It should be administered preferably 30-60 min before the main meals.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Review renal impairment dosing; many agents need CrCl/eGFR adjustment.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Review hepatic impairment dosing; monitor LFTs if agent is hepatically cleared or hepatotoxic.
Use, effects & interactions
Indications
- Appetite stimulation, weight gain and non-hormonal anabolizing agent.
- Clinical selection for Metopine / Lysine / Carnitine / Vit B1 / B6 / B12 should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Therapeutic agent (verify pharmacological class).
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- [From component Lysine acetyl salicylate] GI disturbances, hypersensitivity reactions, blood dyscrasia, blurred vision, thirst, fever, increased bleeding time, bronchospasm.
Drug interactions
Open multi-drug checker ↗- Fixed-dose/multi-ingredient product.
- Clinical details partially inherited from component monographs: Lysine acetyl salicylate.
- Confirm combination SmPC for exact dosing.
Mechanism & disposition
Metopine stimulates the appetite by acting at hypothalmic level.
Read complete mechanism
Metopine stimulates the appetite by acting at hypothalmic level. L-carnitine is necessary for normal mammalian fat utilization and energy metabolism. L-Carnitine also stimulates GI and pancreatic secretions. L-lysine is important for protein synthesis.
Product-specific
Product-specific
See product SmPC
are product-specific. Consider food effects, protein binding, hepatic CYP/UGT
when adjusting for organ impairment, age and drug interactions. Verify parameters in the current SmPC.
Pregnancy, lactation & diet
[Metopine] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Carnitine] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
[Metopine] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [Carnitine] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| TRIMETABOL | DAIMA BIASHARA / Wholesale Import | SYRUP 150ML | KES 725.63Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.