Clinical medicine profile
Oxytocin / Ergometrine
Adrenocorticotropic Hormone [EPC], Oxytocic [EPC], Thyroid Stimulating Hormone [EPC]
- Route
- See product SmPC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- [Oxytocin] Hypersensitivity to the active substance or excipients.
- Additional absolute contraindications are indication- and product-specific — consult SmPC. [Ergometrine] Hypersensitivity to the active substance or excipients.
- Additional absolute contraindications are indication- and product-specific — consult SmPC.
Precautions
- WARNINGS Stop use and ask doctor if symptoms persist more than 5 days.
- If pregnant or breast-feeding ask a health professional before use.
- Keep out of reach of children.
- In case of overdose, get medical help or contact a Poison Control Center right away.
- Contains ethyl alcohol 30%
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
DIRECTIONS Take 15 minutes before meals Adults : 20 drops in a little water, 2 times per day
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Review renal impairment dosing; many agents need CrCl/eGFR adjustment.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Review hepatic impairment dosing; monitor LFTs if agent is hepatically cleared or hepatotoxic.
Use, effects & interactions
Indications
- Therapeutic use is agent- and indication-specific within the class (Therapeutic agent (verify pharmacological class)).
- Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
- Post-partum uterine haemorrhage
Adverse effects
- [From component Oxytocin] Fibrinogenaemia
- pelvic haematoma
- postpartum haemorrhage: allergic reactions
- cardiac arrhythmias
- hypotension followed by hypertension
- uterine rupture
- water intoxication
- vomiting.
Drug interactions
Open multi-drug checker ↗- Professional use: confirm indication, dose, duration, monitoring and patient counselling points against current Kenya STG / EML and the product SmPC.
- Document allergy status and key interactions.
Mechanism & disposition
Combination product.
Read complete mechanism
Combination product. Component mechanism (Oxytocin): It acts by increasing intracellular calcium concentrations in the uterine myometrium, which contains receptors specific to oxyto- cin, thus inducing contractions. It induces lactation by stimulating smooth muscle to help dis- charge of milk from breasts
Product-specific
Product-specific
See product SmPC
are product-specific. Consider food effects, protein binding, hepatic CYP/UGT
when adjusting for organ impairment, age and drug interactions. Verify parameters in the current SmPC.
Pregnancy, lactation & diet
[Oxytocin] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [Ergometrine] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
[Oxytocin] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [Ergometrine] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.