AfyaIndex
Kenyan Reference & Directory
Free lookups: 2/3 Unlock Pro
Clinical reference Find a medicine
Ctrl K
Drug categories Interaction checker
2 of 3 free lookups remaining Upgrade
New search Medicine profile Sodium Bicarbonate 1716mg+Tartaric acid 858mg+Citric Acid 702mg+Sodium Citrate 613mg per 4gm
Check interactions

Clinical medicine profile

Sodium Bicarbonate 1716mg+Tartaric acid 858mg+Citric Acid 702mg+Sodium Citrate 613mg per 4gm

Therapeutic agent (verify pharmacological class)

POM
Evidence state Source-linked Review date not recorded
Route
INTRATHECAL
Schedule
POM
ATC
Not assigned
PPB status
registered
Patient advice Check interactions
01 Risk first

Safety essentials

The information most likely to change a prescribing or dispensing decision.

Contraindications

  • [Bicarbonate] [From component Sodium bicarbonate] Hypertension
  • convulsions
  • metabolic and respiratory alkalosis
  • hypocalcaemia in which alkalosis may produce tetany
  • losing chloride by vomiting or by continous GI suction
  • receiving diuretic that cause hypochloremic alkalosis.

Precautions

  • WARNINGS Intrathecal administration of drugs such as methotrexate sodium and cytarabine should be performed by personnel skilled in the technique of lumbar puncture under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents.
  • The labeling for methotrexate sodium and cytarabine should be consulted.
02 Point of care

Dosing matrix

Population and organ-function guidance, shown together for faster comparison.

Adult

DOSAGE AND ADMINISTRATION See product labeling for methotrexate sodium and cytarabine. Elliotts B Solution is intended for intrathecal administration only. Elliotts B Solution does not contain antibacterial preservatives and introduction of contaminated solutions into the cerebrospinal fluid may have extremely serious consequences. Therefore, administration of intrathecal solutions should be accomplished as soon as possible after preparation. A sterile filter-needle should be used to withdraw the contents of the ampule. Intrathecal drug products should be inspected visually for particulate matter and discoloration prior to administration. Preparation and Administration Precautions Elliotts B Solution is a diluent for the cytotoxic anticancer agents, methotrexate sodium and cytarabine. Care should be exercised in the handling and preparation of infusion solutions with these products. (See product labeling for methotrexate sodium and cytarabine.)

Paediatric

See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.

Renal

Review renal impairment dosing; many agents need CrCl/eGFR adjustment.

  • CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Hepatic

Review hepatic impairment dosing; monitor LFTs if agent is hepatically cleared or hepatotoxic.

03 Clinical use

Use, effects & interactions

Indications

Heartburn, indigestion, as a urinary alkalinizing agent it can be used to alleviate symptoms associated with inflammatory conditions of the bladder and it can be used to prevent crystalluria during sulphonamide treatment.

Adverse effects

  • ADVERSE REACTIONS Adverse reactions may occur with any given intrathecal injection due to the chemotherapy or the technique of intrathecal administration.
  • (See product labeling for methotrexate sodium and cytarabine.) Preservative-free methotrexate sodium and cytarabine should be used to minimize adverse reactions due to preservatives.
  • If an adverse reaction does occur, discontinue the administration, evaluate the patient, institute appropriate therapeutic countermeasures and, if possible, save the remainder of the unused solution(s) for examination.

Drug interactions

Open multi-drug checker ↗
  • Fixed-dose/multi-ingredient product.
  • Clinical details partially inherited from component monographs: Sodium bicarbonate.
  • Confirm combination SmPC for exact dosing.
04 Pharmacology

Mechanism & disposition

Combination product.

Combination product.Component mechanism (Sodium bicarbonate):…At receptor, enzyme, ion channel, transpor…
Read complete mechanism

Combination product. Component mechanism (Sodium bicarbonate): Monitoring potassium depletion and chloride loss Mechanism is agent-specific. At receptor, enzyme, ion channel, transporter or microbial target level, the drug alters a physiological or pathological pathway to produce its therapeutic effect. Confirm precise molecular mechanism in current SmPC / pharmacology reference for this INN before high-stakes decisions.

Onset

Product-specific

Duration

Product-specific

Route

INTRATHECAL

05 Special populations

Pregnancy, lactation & diet

Pregnancy

Usage in Pregnancy All components of Elliotts B Solution are normal body constituents. Animal reproduction studies have not been conducted with Elliotts B Solution.

Lactation

Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.

06 Kenya market

Brands & loaded prices

From—
Median—
Listings0
BrandManufacturerPackObserved price
No reviewed brand listings are linked yet.
07 Provenance

Sources & review state

Primary sourceLocal active-ingredient clinical extract; FDA drug label via OpenFDA/DailyMed; Component monographs (multi-source pipeline); Professional class pharmacology (Therapeutic agent (verify pharmacological class))
Last reviewedNot recorded
EvidenceSource-linked
Open source document ↗

Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.