Clinical medicine profile
Vitamin A
Vitamin A [EPC], Vitamin C [EPC]
- Route
- ORAL / IM / IV (selected)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's.
Precautions
- Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal).
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
DOSAGE AND ADMINISTRATION 1.0 mL daily or as directed by physician. May be dropped directly into the mouth with dropper; or mixed with cereal, fruit juice or other food. Tri-Vite Drops with Fluoride 0.25 mg is available in 50 mL bottles with accompanying calibrated dropper.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fat-soluble vitamins and potassium need care in advanced CKD.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.
Use, effects & interactions
Indications
- INDICATIONS AND USAGE Supplementation of the diet with vitamins A, C and D.
- Tri-Vite Drops with Fluoride 0.25 mg also provides fluoride for caries prophylaxis.
- The American Academy of Pediatrics recommends that children up to age 16, in areas where drinking water contains less than optimal levels of fluoride, receive daily fluoride supplementation.
- The American Academy of Pediatrics recommend that infants and young children 6 months to 3 years of age, in areas where the drinking water contains less than 0.3 ppm of fluoride, and children 3-6 years of age, in areas where the drinking water contains 0.3 through 0.6 ppm of fluoride, receive 0.25 mg of supplemental fluoride daily which is provided in a dose of 1 mL of Tri-Vite Drops with Fluoride 0.25 mg (See Dosage and Administration ).
- Tri-Vite Drops with Fluoride 0.25 mg supply significant amounts of vitamins A, C and D to supplement the diet, and to help assure that nutritional deficiencies of these vitamins will not develop.
- Thus, in a single easy-to-use preparation, children obtain essential vitamins and fluoride.
Adverse effects
- GI upset (iron, high-dose vitamin C).
- Hypercalcaemia (vitamin D excess).
- Neuropathy with B6 megadoses.
- Flushing (niacin).
Drug interactions
Open multi-drug checker ↗- Prefer food-first then targeted replacement.
- Document laboratory indication for high-dose therapy.
- Public health: vitamin A, iron, folate programmes per MoH guidance.
Mechanism & disposition
It combines with opsin, which is the red pigment in the retina to form rhodopsin [visual purple] when it is in form of retinol.
Read complete mechanism
It combines with opsin, which is the red pigment in the retina to form rhodopsin [visual purple] when it is in form of retinol. Rhodopsin is necessary for visual adaptation to darkness. Retinol and retinoic acid, being other forms of Vitamin A, are essential for growth of bone, testicular and ovarian function, for embryonic development, and for regulation of growth and differentiation of epithelial tissues.
Days–weeks for repletion
Depends on stores and ongoing intake
ORAL / IM / IV (selected)
Pregnancy, lactation & diet
Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A.
Maternal repletion often appropriate; avoid megadoses.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.