Biphasic and Intermediate Acting Insulins

Insulin Glargine Indications Diabetes mellitus Dose General dosage of insulins: The starting dose should be 10-16 units of soluble insulin SC 15-30 minutes (depending on the type of insulin) before meal TID. The dose is adjusted gradually in 5 unit aliquots to achieve plasma glucose range of 8.3-13.4 mmol/L in hospital and target the range of 4-10mmol/L at home. Once the blood glucose stabilizes at 8-11.0 mmol/L the patient is switched to the intermediate insulin whose dose is 2/3 of the total dose of soluble insulin. Normally 2/3 of the intermediate insulin is administered in the morning and 1/3 before supper. For more information, click the links below Mode Of Action Precautions Contraindications Side Effects Pregnancy Risk Category Special Information Brands Show entries Search: Name Formulation Strength Pack size Cost Manufacturer Distributor No data available in table Showing 0 to 0 of 0 entries PreviousNext Sponsored Ads Quick Links Contacts Keep in touch Terms and conditions Privacy 2018 Drug Index Mode Of Action Insulin: ||| controls the storage and metabolism of carbohydrates, proteins, and fats. This occurs primarily in the liver, in muscle, and in adipose tissues after it binding to receptor sites on cellular plasma membranes. ||| is known to affect cell membrane transport characteristics, cellular growth, enzyme activation and inhibition, and changes in protein and fat metabolism. ||| promotes uptake of carbohydrates, proteins, and fats in most tissues. stimulates protein and free fatty acid synthesis. It inhibits release of free fatty acid from adipose cells. ||| increases active glucose transport through muscle and adipose cellular membranes ||| promotes conversion of intracellular glucose to glycogen and free fatty acid to triglyceride [storage forms] ||| increases hepatic glucose conversion to glycogen and suppresses hepatic glucose output. ||| stimulates growth hormonferre secretion by producing hypoglycemia, which is used to evaluate pituitary growth hormone reserve. ||| increases the intracellular shift of potassium and magnesium and decreases renal excretion of sodium. ||| decreases the synthesis of high-density lipoprotein [HDL] cholesterol and increases the synthesis of very low-density lipoprotein [VLDL] cholesterol in the liver. ||| increases lipoprotein uptake and utilization in the lactating mammary gland. ||| stimulates activity of and tissue response to the sympathetic nervous system.