Clinical medicine profile
Calcium Dobesilate
Vitamin / mineral / nutritional supplement
- Route
- ORAL / IM / IV (selected)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
A traceable source link is not attached to this profile. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's.
Precautions
- Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal).
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
500-1000mg daily in divided doses for 4-6 months followed by 500mg OD.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fat-soluble vitamins and potassium need care in advanced CKD.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.
Use, effects & interactions
Indications
- Diabetic retinopathy
- varicose vein
- hemorrhoids
- myocardial infarction.
- Clinical selection for Calcium Dobesilate should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Vitamin / mineral / nutritional supplement.
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- GI upset (iron, high-dose vitamin C).
- Hypercalcaemia (vitamin D excess).
- Neuropathy with B6 megadoses.
- Flushing (niacin).
Drug interactions
Open multi-drug checker ↗- Prefer food-first then targeted replacement.
- Document laboratory indication for high-dose therapy.
- Public health: vitamin A, iron, folate programmes per MoH guidance.
Mechanism & disposition
It increases endothelial nitric oxide levels by increasing the activity of nitric oxide synthase and decreasing capillary hyperpermeability.
Read complete mechanism
It increases endothelial nitric oxide levels by increasing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. It has also some anti-platelet and fibrinolytic activities.
Days–weeks for repletion
Depends on stores and ongoing intake
ORAL / IM / IV (selected)
depends on GI integrity, food matrix and binders (e.g. calcium/iron interactions). Fat-soluble vitamins (A,D,E,K) accumulate; water-soluble generally renally cleared.
Pregnancy, lactation & diet
Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A.
Maternal repletion often appropriate; avoid megadoses.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| Dobesil | Ochoa | tabs 30's | Unavailable |
| DOBESIL | DAIMA BIASHARA / Wholesale Import | 500MG CAPS 50`S | KES 2,586.45Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| Doxium 500mg Capsules | OM PHARMA | Hard Gelatin Capsules 500mg | Unavailable |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.