Clinical medicine profile
Dry aluminium hydroxide 200mg/magnesium trisilicate/sodium alginate 100mg/ simethicone 25mg
Vitamin / mineral / nutritional supplement
- Route
- ORAL / IM / IV (selected)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
A traceable source link is not attached to this profile. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- [Dry aluminium hydroxide] Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's. [magnesium trisilicate] Hypervitaminosis risk states (hypercalcaemia for vitamin D/A).
- Iron: avoid in iron overload.
- Potassium: severe hyperkalaemia / untreated Addison's. [alginate] Hypersensitivity to the active substance or excipients.
- Additional absolute contraindications are indication- and product-specific — consult SmPC. [simethicone] Hypersensitivity to the active substance or excipients.
- Additional absolute contraindications are indication- and product-specific — consult SmPC.
Precautions
- [Dry aluminium hydroxide] Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal). [magnesium trisilicate] Treat confirmed deficiency with monitored repletion.
- Avoid megadoses without indication.
- Iron: keep away from children (overdose lethal). [alginate] WARNINGS: Professional Use Only If pregnant or breast-feeding, ask a health professional before use.
- In case of overdose, get medical help or contact a Poison Control Center right away.
- If condition worsens, seek medical attention.
- KEEP OUT OF REACH OF CHILDREN Do not use if tamper evident seal is broken or missing.
- Store in a cool place after opening [simethicone] Obtain allergy and medication history.
- Adjust for renal/hepatic impairment, pregnancy, lactation, extremes of age and interacting drugs.
- Use the lowest effective dose for the shortest appropriate duration.
- Monitor for expected class adverse effects.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
Adults: 5-10mL, 20 - 60 min after meals and at bedtime when required. Children under 5 years: Maximum of 5ml TID.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fat-soluble vitamins and potassium need care in advanced CKD.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Vitamin A toxicity hepatic; niacin hepatotoxicity at high dose.
Use, effects & interactions
Indications
- Therapeutic use is agent- and indication-specific within the class (Vitamin / mineral / nutritional supplement).
- Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
- Dyspepsia, heartburn, and flatulence.
Adverse effects
- [Dry aluminium hydroxide] GI upset (iron, high-dose vitamin C).
- Hypercalcaemia (vitamin D excess).
- Neuropathy with B6 megadoses.
- Flushing (niacin). [magnesium trisilicate] GI upset (iron, high-dose vitamin C).
- Hypercalcaemia (vitamin D excess).
- Neuropathy with B6 megadoses.
- Flushing (niacin). [alginate] Adverse reactions vary by agent.
- Counsel on common predictable effects and serious warning symptoms (allergy, severe rash, jaundice, unusual bleeding, severe GI symptoms, neurological changes).
- Report suspected ADRs via national pharmacovigilance channels. [simethicone] Adverse reactions vary by agent.
- Counsel on common predictable effects and serious warning symptoms (allergy, severe rash, jaundice, unusual bleeding, severe GI symptoms, neurological changes).
- Report suspected ADRs via national pharmacovigilance channels.
Drug interactions
Open multi-drug checker ↗- Prefer food-first then targeted replacement.
- Document laboratory indication for high-dose therapy.
- Public health: vitamin A, iron, folate programmes per MoH guidance.
Mechanism & disposition
Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.
Read complete mechanism
Vitamins and minerals act as cofactors, antioxidants, structural elements or hormone precursors (e.g. vitamin D endocrine axis). Pharmacological high-dose effects differ from nutritional repletion.
Days–weeks for repletion
Depends on stores and ongoing intake
ORAL / IM / IV (selected)
depends on GI integrity, food matrix and binders (e.g. calcium/iron interactions). Fat-soluble vitamins (A,D,E,K) accumulate; water-soluble generally renally cleared.
Pregnancy, lactation & diet
[Dry aluminium hydroxide] Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A. [magnesium trisilicate] Folic acid preconception/first trimester critical. Iron/folate common in ANC. Avoid excess vitamin A. [alginate] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist. [simethicone] Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
[alginate] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data. [simethicone] Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.