Clinical medicine profile
Ebastine
Therapeutic agent (verify pharmacological class)
- Route
- See product SmPC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
Some sections contain general class guidance rather than medicine-specific evidence. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Hypersensitivity to the active substance or excipients.
- Additional absolute contraindications are indication- and product-specific — consult SmPC.
Precautions
- Obtain allergy and medication history.
- Adjust for renal/hepatic impairment, pregnancy, lactation, extremes of age and interacting drugs.
- Use the lowest effective dose for the shortest appropriate duration.
- Monitor for expected class adverse effects.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
10-20mg daily. A dose of 10mg /day should not be exceeded in case of hepatic failure.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Review renal impairment dosing; many agents need CrCl/eGFR adjustment.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Review hepatic impairment dosing; monitor LFTs if agent is hepatically cleared or hepatotoxic.
Use, effects & interactions
Indications
- Allergic rhinnitis [seasonal and perennial]
- idiopathic chronic urticaria Clinical selection for Ebastine should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Therapeutic agent (verify pharmacological class).
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- Adverse reactions vary by agent.
- Counsel on common predictable effects and serious warning symptoms (allergy, severe rash, jaundice, unusual bleeding, severe GI symptoms, neurological changes).
- Report suspected ADRs via national pharmacovigilance channels.
Drug interactions
Open multi-drug checker ↗- Professional use: confirm indication, dose, duration, monitoring and patient counselling points against current Kenya STG / EML and the product SmPC.
- Document allergy status and key interactions.
Mechanism & disposition
An antihistamine with poor blood brain barrier penetration.
Read complete mechanism
An antihistamine with poor blood brain barrier penetration. It is devoid of cholinergic and CNS side effects Mechanism is agent-specific. At receptor, enzyme, ion channel, transporter or microbial target level, the drug alters a physiological or pathological pathway to produce its therapeutic effect. Confirm precise molecular mechanism in current SmPC / pharmacology reference for this INN before high-stakes decisions.
Product-specific
Product-specific
See product SmPC
are product-specific. Consider food effects, protein binding, hepatic CYP/UGT
when adjusting for organ impairment, age and drug interactions. Verify parameters in the current SmPC.
Pregnancy, lactation & diet
Use only if potential benefit justifies potential risk; prefer agents with better reproductive data when alternatives exist.
Assess infant risk vs benefit of maternal therapy; prefer agents with lactation data.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| EBAMIN 10MG TABLETS | MEDCURE HEALTHCARE LTD | Film-Coated Tablet 10MG | Unavailable |
| EBAMIN SYRUP | MEDCURE HEALTHCARE LTD | Syrup | Unavailable |
| EBASTINE | Not recorded | SYRUP 5MG/5ML 60ML(HISTY) | KES 383.77Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| EROSTIN | DAIMA BIASHARA / Wholesale Import | SUSP 5MG/5ML 60ML | KES 456.44Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| ERSOTIN 10 | Micro Labs Ltd | Tablet | Unavailable |
| HISTY | Not recorded | TABS 20MG 10*S | KES 456.88Daima Chemist price-list reference ↗ Source date not recorded · verify current price |
| HISTY SYRUP | KRISHNA CHEMISTS LTD | Oral Liquid | Unavailable |
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.