Clinical medicine profile
Fluticasone propionate nasal spray
Corticosteroid
- Route
- ORAL / IV / IM / INHALED / TOPICAL / NASAL / OPHTHALMIC
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
This profile needs source confirmation
A traceable source link is not attached to this profile. Confirm prescribing decisions against the current SmPC and Kenya STG/EML.
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Systemic fungal infections (untreated) for systemic steroids.
- Live vaccines with significant immunosuppression.
- Hypersensitivity.
- Topical: untreated skin infection at site (relative).
Precautions
- Shortest course, lowest dose.
- Taper after prolonged systemic use.
- Infection risk, hyperglycaemia, BP rise, mood changes, osteoporosis, avascular necrosis, glaucoma/cataract.
- Adrenal insufficiency on withdrawal.
- Stress-dose cover if indicated.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
Children 4-11yrs: inhale into each nostril OD, increased to BD [max. 4 sprays daily]. Adults and children over 12yrs: inhale two sprays OD to a max. of 8 sprays daily.
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Fluid retention/hypertension — care in renal disease.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Prednisone needs hepatic activation to prednisolone.
Use, effects & interactions
Indications
- Therapeutic use is agent- and indication-specific within the class (Corticosteroid).
- Use according to culture results, national guidelines (Kenya STG/EML where applicable) and the current product SmPC.
Adverse effects
- Insomnia, increased appetite, mood lability, dyspepsia, hyperglycaemia.
- Chronic: cushingoid features, myopathy, osteoporosis, HPA suppression.
- Topical: skin atrophy, striae.
- Inhaled: thrush, dysphonia.
Drug interactions
Open multi-drug checker ↗- State indication and planned duration on every prescription.
- Bone protection if prolonged.
- Screen for strongyloides risk before prolonged high-dose in endemic exposure.
- ICS: spacer + rinse mouth.
Mechanism & disposition
Corticosteroids bind intracellular glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokines, inhibit phospholipase A2 via lipocortins, reduce leukocyte migration and stabilise membranes — potent anti-inflammatory and immunosuppressive effects.
Read complete mechanism
Corticosteroids bind intracellular glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokines, inhibit phospholipase A2 via lipocortins, reduce leukocyte migration and stabilise membranes — potent anti-inflammatory and immunosuppressive effects. Mineralocorticoid activity varies by agent.
Hours–days
Agent and route dependent
ORAL / IV / IM / INHALED / TOPICAL / NASAL / OPHTHALMIC
Pregnancy, lactation & diet
Used when maternal benefit clear; prefer agents with better obstetric data (e.g. prednisolone). Document risk–benefit.
Low-dose systemic often compatible; time feeds if high dose — agent-specific.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.