Clinical medicine profile
Guaifenesin BP 100mg, Bromhexine Hydrochloride BP 4mg, Salbutamol Sulphate BP 2mg
Expectorant [EPC]
- Route
- INHALATION / ORAL / NEB / IV (rare)
- Schedule
- POM
- ATC
- Not assigned
- PPB status
- registered
Safety essentials
The information most likely to change a prescribing or dispensing decision.
Contraindications
- Hypersensitivity.
- LABA monotherapy in asthma is contraindicated — always with ICS.
Precautions
- Warnings Do not use in child who is taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional condition, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
- If you do not know if your child’s prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product.
Dosing matrix
Population and organ-function guidance, shown together for faster comparison.
Directions Do not give more than 6 doses in any 24 hours period shake well before use measure only with dosing cup provided keep dosing cup with product mL = milliliter Age Dose Children 6 to under 12 years of age 5 mL every 4 hours Children 4 to under 6 years of age 2.5 mL every 4 hours Children under 4 years of age Do not use
See label paediatric section if present; otherwise use paediatric formulary — do not extrapolate adult doses.
Low for inhaled; monitor electrolytes if continuous nebs.
- CrCl 0–120: Confirm renal dosing in product SmPC / primary label.
Low clinical concern for inhaled therapy.
Use, effects & interactions
Indications
- Uses Uses: temporarily relieves cough due to minor throat and bronchial irritation as may occur with a cold helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes.
- Clinical selection for Guaifenesin BP 100mg, Bromhexine Hydrochloride BP 4mg, Salbutamol Sulphate BP 2mg should follow culture results where relevant, Kenya STG/EML recommendations, and the current product SmPC.
- Class context: Expectorant [EPC].
- Confirm site-specific dose, duration and monitoring before prescribing.
Adverse effects
- Tremor, tachycardia, headache, palpitations, hypokalaemia, hyperglycaemia.
- Serious: arrhythmias, paradoxical bronchospasm.
Drug interactions
Open multi-drug checker ↗- Assess inhaler technique every visit.
- Increasing SABA use = uncontrolled disease — step up controller therapy.
- Never prescribe LABA alone for asthma.
Mechanism & disposition
Stimulate airway smooth muscle beta-2 receptors, increasing cAMP and causing bronchodilation.
Read complete mechanism
Stimulate airway smooth muscle beta-2 receptors, increasing cAMP and causing bronchodilation. Also improve mucociliary clearance and may stabilise mast cells. SABA for rescue; LABA for maintenance with ICS.
Minutes (SABA)
3–6 h SABA; 12 h LABA
INHALATION / ORAL / NEB / IV (rare)
causes tremor/tachycardia. Hepatic
of many agents.
Pregnancy, lactation & diet
Inhaled salbutamol widely used; uncontrolled asthma risk > drug risk.
Inhaled therapy generally compatible.
Brands & loaded prices
| Brand | Manufacturer | Pack | Observed price |
|---|---|---|---|
| No reviewed brand listings are linked yet. | |||
Sources & review state
Decision support only. Confirm patient-specific decisions against the current product SmPC, Kenya STG/EML, and professional judgement.